Dosage should be based on body weight; a 200 lb. person will need approximately twice as much of a supplement as a 100 lb. person. The directions below are primarily from the manufacturer(s) for the average 150-160 lb. man or woman. Suggested use: 1 drop CLO2 per ounce of water. Up to 30 drops per day. Start with 10 drops in a liter of water (33 ounces) to a maximum of 30 drops and drink throughout the day. (Should be taken with the E3 Probiotic).